24 US AI Startups That Secured $100M+ in 2025: The Future of Innovation
Techcrunch•5 hours ago•
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24 US AI Startups That Secured $100M+ in 2025: The Future of Innovation

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Summary:

  • 24 US AI startups have raised $100 million or more in 2025

  • OpenAI leads with a $40 billion funding round and a $300 billion valuation

  • Anthropic and Glean also secured massive funding, with valuations of $61.5 billion and $7.25 billion respectively

  • The AI sector continues to attract significant investment, with startups in drug discovery, legal tech, and infrastructure leading the charge

  • 2025 is on track to surpass 2024's record-breaking funding levels in the AI industry

The Rise of AI Startups in 2025

Last year marked a significant milestone for the AI industry, with 49 startups raising funding rounds worth $100 million or more in 2024. The momentum has continued into 2025, with several AI startups already securing massive funding rounds. Here's a look at the 24 US AI startups that have raised $100 million or more this year.

June Highlights

  • Glean: Raised a $150 million Series F round, valuing the company at $7.25 billion.
  • Anysphere: Secured a $900 million Series C round, reaching a $10 billion valuation.

May Highlights

  • Snorkel AI: Announced a $100 million Series D round, valuing the company at $1.3 billion.
  • LMArena: Raised a $100 million seed round, with a $600 million valuation.
  • TensorWave: Closed a $100 million Series A round.

April Highlights

  • SandboxAQ: Secured a $450 million Series E round, valuing the company at $5.7 billion.
  • Runway: Raised a $308 million Series D round, reaching a $3 billion valuation.

March Highlights

  • OpenAI: Raised a record-breaking $40 billion funding round, valuing the startup at $300 billion.
  • Nexthop AI: Announced a $110 million Series A round.
  • Insilico Medicine: Raised $110 million for its AI-powered drug discovery platform.
  • Celestial AI: Secured a $250 million Series C round, valuing the company at $2.5 billion.
  • Lila Sciences: Raised a $200 million seed round.
  • Reflection.Ai: Closed a $130 million Series A round, valuing the company at $580 million.
  • Turing: Raised a $111 million Series E round, reaching a $2.2 billion valuation.
  • Shield AI: Secured a $240 million Series F round, valuing the company at $5.3 billion.
  • Anthropic: Raised $3.5 billion in a Series E round, reaching a $61.5 billion valuation.

February Highlights

  • Together AI: Raised a $305 million Series B round, valuing the company at $3.3 billion.
  • Lambda: Secured a $480 million Series D round, reaching a $2.5 billion valuation.
  • Abridge: Raised a $250 million Series D round, valuing the company at $2.75 billion.
  • Eudia: Closed a $105 million Series A round.
  • EnCharge AI: Raised a $100 million Series B round.
  • Harvey: Secured a $300 million Series D round, reaching a $3 billion valuation.

January Highlights

  • ElevenLabs: Raised a $180 million Series C round, valuing the company at over $3 billion.
  • Hippocratic AI: Announced a $141 million Series B round, reaching a $1.6 billion valuation.

This list showcases the continued growth and investment in the AI sector, with startups across various domains securing significant funding to drive innovation forward.

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